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Yoda 1
CAS No. 448947-81-7
Yoda 1( —— )
Catalog No. M20782 CAS No. 448947-81-7
Yoda1 is a Piezo1 ion channel agonist (EC50s = 17.1 and 26.6 μM for murine and human Piezo1-transfected HEK293T cells respectively).
Yoda1 is a Piezo1 ion channel agonist (EC50s = 17.1 and 26.6 μM for murine and human Piezo1-transfected HEK293T cells respectively).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 50 | In Stock |
|
| 5MG | 78 | In Stock |
|
| 10MG | 105 | In Stock |
|
| 25MG | 219 | In Stock |
|
| 50MG | 423 | In Stock |
|
| 100MG | 620 | In Stock |
|
| 500MG | 1314 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameYoda 1
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NoteResearch use only, not for human use.
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Brief DescriptionYoda1 is a Piezo1 ion channel agonist (EC50s = 17.1 and 26.6 μM for murine and human Piezo1-transfected HEK293T cells respectively).
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DescriptionYoda1 is a Piezo1 ion channel agonist (EC50s = 17.1 and 26.6 μM for murine and human Piezo1-transfected HEK293T cells respectively).
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In VitroWestern Blot Analysis Cell Line:human coronary artery endothelial cells (HCAECs), A431 cellsConcentration:0, 1.5, 3.0, and 6.0?μM Incubation Time:5 min Result:Induced the activation of both Akt and ERK1/2, and increased the phosphorylation levels of both Akt and ERK1/2 in a dose-dependent manner. Inhibited EGF-induced increase in the amount of Rac1-GTP, and inhibited Rac1 activation
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorPiezo1
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Research Area——
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Indication——
Chemical Information
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CAS Number448947-81-7
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Formula Weight355.27
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Molecular FormulaC13H8Cl2N4S2
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Purity>98% (HPLC)
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SolubilityDMSO:34 mg/mL (95.70 mM)
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SMILESClc1cccc(Cl)c1CSc1nnc(-c2cnccn2)s1
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Chemical Name2-[5-(26-Dichloro-benzylsulfanyl)-[134]thiadiazol-2-yl]-pyrazine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Ruhma S Jie X Dubin A E et al. Chemical activation of the mechanotransduction channel Piezo1[J]. eLife 2015 4.
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