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Yoda 1

CAS No. 448947-81-7

Yoda 1( —— )

Catalog No. M20782 CAS No. 448947-81-7

Yoda1 is a Piezo1 ion channel agonist (EC50s = 17.1 and 26.6 μM for murine and human Piezo1-transfected HEK293T cells respectively).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Yoda 1
  • Note
    Research use only, not for human use.
  • Brief Description
    Yoda1 is a Piezo1 ion channel agonist (EC50s = 17.1 and 26.6 μM for murine and human Piezo1-transfected HEK293T cells respectively).
  • Description
    Yoda1 is a Piezo1 ion channel agonist (EC50s = 17.1 and 26.6 μM for murine and human Piezo1-transfected HEK293T cells respectively).
  • In Vitro
    Western Blot Analysis Cell Line:human coronary artery endothelial cells (HCAECs), A431 cellsConcentration:0, 1.5, 3.0, and 6.0?μM Incubation Time:5 min Result:Induced the activation of both Akt and ERK1/2, and increased the phosphorylation levels of both Akt and ERK1/2 in a dose-dependent manner. Inhibited EGF-induced increase in the amount of Rac1-GTP, and inhibited Rac1 activation
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Piezo1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    448947-81-7
  • Formula Weight
    355.27
  • Molecular Formula
    C13H8Cl2N4S2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:34 mg/mL (95.70 mM)
  • SMILES
    Clc1cccc(Cl)c1CSc1nnc(-c2cnccn2)s1
  • Chemical Name
    2-[5-(26-Dichloro-benzylsulfanyl)-[134]thiadiazol-2-yl]-pyrazine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Ruhma S Jie X Dubin A E et al. Chemical activation of the mechanotransduction channel Piezo1[J]. eLife 2015 4.
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